Preclinical efficacy assay

Our company has an international team with excellent professional skills in areas covering pharmacology, neuropharmacology, cell biology, molecular pharmacology, immunology, veterinary, toxicology, medicine, etc. Our business includes large-scale in vitro and in vivo screening of gene therapy therapeutic materials , cytokines, antibody therapeutic materials s, protein therapeutic materials s and chemical therapeutic materials s (small and large molecules), and preclinical effectiveness evaluation research applicable to domestic and foreign applications. Our company is good at the following projects, we can also carry out other types of research according to customer needs.

In vitro tests:

    Single cell gene sequencing

    High throughput screening of kinase inhibitors

    Computer simulation of high-throughput therapeutic material design

    therapeutic materials  permeability test (CaCO cells, isolated skin)

    High-throughput screening of anticancer therapeutic materials s in vitro (cytotoxicity test)

    In vitro metabolic test (stability, metabolites, metabolic pathway test)

    Flow cytometry

    Enzyme linked immunosorbent assay

    Receptor/ligand binding test

    Antigen antibody binding test

    Protein/nucleic acid sequencing

    Protein structure analysis

    In vitro detection of antiviral therapeutic materials activity (hepatitis B, AIDS, enterovirus, coronavirus, etc.)

Animal models

    Tumor: subcutaneous transplantation tumor, orthotarget transplantation tumor (lung, liver, brain), immune reconstitution mouse tumor model

    Ophthalmic diseases: dry eye, optic nerve degeneration, macular degeneration, cataract, etc

    Blood system diseases: coagulation, neutropenia, thrombocytopenia, anemia

    Screening models of analgesic therapetuic materials s: hot plate method, writhing method, ear swelling method

    Neuropsychiatric diseases: therapetuic materials  addiction, withdrawal, dementia in mice

    Cardiovascular and cerebrovascular diseases: atherosclerosis, myocardial infarction, cerebral embolism

    Metabolic system diseases: diabetes, insulin resistance, obesity, hyperlipidemia (PCSK9 target therapetuic materials ), hyperuricemia

    Liver diseases: alcoholic and nonalcoholic fatty liver, liver fibrosis, cirrhosis, liver ascites

    Infectious diseases: hepatitis B, viral infection (influenza), bacterial infection

    Urinary system diseases: therapetuic materials  induced renal injury, operation induced renal injury, endometritis, renal insufficiency, etc

    Respiratory diseases: pulmonary fibrosis, pulmonary embolism, asthma, neonatal respiratory distress syndrome, pulmonary hypertension

    Immune related diseases: arthritis (CIA, AIA), multiple sclerosis, TNF - α target therapetuic materials  in vivo neutralization test, GVHD

    Others: skin itching, allergic dermatitis, eczema